Depletion of intracellular calcium stores facilitates the influx of extracellular calcium in platelet derived growth factor stimulated A172 glioblastoma cells
نویسندگان
چکیده
منابع مشابه
a-Difluoromethylornithine Alters Calcium Signaling in Platelet-derived Growth Factor-stimulated A172 Brain Tumor Cells in Culture I
a-Difluoromethylornithine (DFMO), an irreversible inhibitor of the polyamine biosynthetic enzyme ornithine decarboxylase, inhibits the growth of brain tumor cell lines and is undergoing clinical trials as a treatment for brain tumors. Platelet-derived growth factor (PDGF) is thought to regulate the growth and development of precursors of both normal and neoplastic astrocytic cells; calcium sign...
متن کاملEffect of Extracellular Calcium Depletion on Atrial Natriuretic Factor Secretion and Gene Expression
Extracellular Ca 2+ <span style="color: #231f20; font-family: Times ...
متن کاملA calcium-induced calcium influx factor, nitric oxide, modulates the refilling of calcium stores in astrocytes.
The roles of nitric oxide are primarily undefined in astrocytes, cells that are active partners in synaptic transmission. Because nitric oxide synthases are present in astrocytes, we imaged the formation of nitric oxide in cultured murine cortical astrocytes using DAF-FM (4-amino-5-methylamino-2',7'-difluorofluorescein diacetate). We demonstrated that physiological concentrations of ATP induced...
متن کاملCalcium influx factor is synthesized by yeast and mammalian cells depleted of organellar calcium stores.
Depletion of endoplasmic reticulum Ca2+ stores leads to the entry of extracellular Ca2+ into the cytoplasm, a process termed capacitative or store-operated Ca2+ entry. Partially purified extracts were prepared from the human Jurkat T lymphocyte cell line and yeast in which Ca2+ stores were depleted by chemical and genetic means, respectively. After microinjection into Xenopus laevis oocytes, th...
متن کاملMobilization of calcium from intracellular stores facilitates somatodendritic dopamine release.
Somatodendritic dopamine (DA) release in the substantia nigra pars compacta (SNc) shows a limited dependence on extracellular calcium concentration ([Ca(2+)](o)), suggesting the involvement of intracellular Ca(2+) stores. Here, using immunocytochemistry we demonstrate the presence of the sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase 2 (SERCA2) that sequesters cytosolic Ca(2+) into the endopl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cytometry
سال: 1996
ISSN: 0196-4763,1097-0320
DOI: 10.1002/(sici)1097-0320(19960501)24:1<64::aid-cyto8>3.0.co;2-i